Seminole County is a county located in the central portion of the U.S. state of Florida. As of the 2020 census, the population was 470,856, making it the 13th-most populated county in Florida. Its county seat and largest city is Sanford. Seminole County is p…Seminole County is a county located in the central portion of the U.S. state of Florida. As of the 2020 census, the population was 470,856, making it the 13th-most populated county in Florida. Its county seat and largest city is Sanford. Seminole County is part of the Orlando-Kissimmee-Sanford, Florida Metropolitan Statistical Area.
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