In the red light district in Mbarara, a city in western Uganda known in part for sex tourism, a sex worker named Lisa Mutoni insists on using condoms when men enter her room, to protect her against HIV and other infections.

The FDA has approved a generic version of lenacapavir (Yeztugo), the world's only twice-a-year shot to prevent HIV -- a big step toward making the drug available inexpensively and more quickly in 120 low- and middle-income countries.