The Trump administration is warning Harvard University that it could take over its patents, worth hundreds of millions of dollars, if a review finds the university hasn’t complied with federal law, an escalation of the continuing negotiations between the White House and America’s oldest university.

The Trump administration on Friday launched an investigation into Harvard’s patents derived from federally funded research, threatening intellectual property potentially worth hundreds of millions of dollars.

The administration doubled down against Harvard, asserting that rising violent crime on campus meant the school should not host international students. It will also review the school’s patents.