Sickle cell disease is the most common haemoglobinopathy, affecting more than 7 million people worldwide.1 Despite ...

We thank Jordan Bakhriansyah and colleagues for their thoughtful commentary on our manuscript from the ATLAS individual patient data meta-analysis.1 Although their conceptual arguments merit ...

Latvia has one of the world's highest rates of alcohol consumption but recent policy changes are starting to lessen direct harms to health. Ed Holt reports.

On Sept 2, 2026, negative results of the phase 3 ASPIRE trial (NCT06617429) of apazunersen in Angelman syndrome were announced in a press release issued after the stock market closed.1 Angelman ...

Russia's invasion and continued conflict have damaged facilities and led to workforce shortages. Ed Holt reports.

Having immersed myself in death and dying for well over a decade—I wrote a book, The Way We Die Now (2016), and was later a member of the Lancet Commission on The Value of Death—it was inevitable that ...

Although climate change represents one of the greatest public health challenges of our time, its impacts on patients with ...

Interstitial lung disease (ILD) is increasingly recognised as a global health problem, yet the true burden remains uncertain ...

Heavy menstrual bleeding is a challenging condition that, when refractory to conventional treatment, frequently culminates in hysterectomy. Endometrial ablation offers an effective, uterus-sparing ...

For decades, the standard of care for patients with resected stage II and III colon cancer has centred on surgery with consideration of postoperative adjuvant systemic therapy to reduce risk of ...

A controversial trial in which a birth dose of hepatitis B vaccine would be withheld from half the enrolled newborn children has been given ethical approval, according to the Center for Infectious ...

Karl Deisseroth, Peter Hegemann, and Georg Nagel have been awarded the 2026 Nobel Prize in Physiology or Medicine. Talha ...