Nearly three decades after the discovery of the orexin (also known as hypocretin) neuropeptides and the identification of orexin deficiency as the cause of narcolepsy type 1,1 orexin 2 receptor (OX2R) ...

The management of advanced hepatocellular carcinoma, defined by the presence of vascular invasion, extrahepatic spread, and ...

The health of LGBTQ+ people has long been an indicator of wider advances in human rights and health equity. Modern LGBTQ+ ...

It has been 40 years since Purdue Pharma released OxyContin in the USA and—through its aggressive marketing, lobbying, and ...

The global humanitarian crisis is escalating due to conflicts, climate-related disasters, and infection outbreaks.1 Recent ...

We call it le Vidal”, Alexandre Loupy says. “It's a 4000-page book that my mother had, with all the medications…I said, okay, ...

In February, 2025, we reported in The Lancet the human toll of the UK's prolonged refusal to introduce newborn screening for spinal muscular atrophy, despite overwhelming international evidence ...

For the past four decades, oral antiretroviral therapy for HIV has required daily doses. Long-acting injectable cabotegravir ...

My doctor told me to lose weight.” As a paediatrician and adolescent medicine specialist practising in the USA with a specialty in eating disorders, I hear a version of this sentence frequently when I ...

The declaration on July 28, 2026, that the Bundibugyo virus outbreak in Uganda had ended marks a crucial milestone in outbreak control.1 WHO considers an Ebola outbreak resolved 42 consecutive days ...

Artificial intelligence (AI)-based prediction models, including risk scoring systems and decision support systems, are being ...

Coronary artery bypass grafting (CABG) remains the standard of care for many patients with complex multivessel coronary artery disease because of its proven durability and long-term survival benefit.1 ...