Conformationally constrained 2-pyridone analogue 2 is a potent Met kinase inhibitor with an IC50 value of 1.8 nM. Further SAR of the 2-pyridone based inhibitors of Met kinase led to potent 4-pyridone ...

We report metal-insulator-semiconductor photodetectors fabricated on a silicon-on-insulator substrate, exhibiting an enhanced responsivity in the near-infrared due to the incorporation of ...