The esophagus, which is not normally exposed to acid, adapts to acid reflux by becoming more like the stomach or the intestine.

If you have Barrett’s esophagus, you know that treatment typically focuses on two things: keeping the condition in check by controlling acid reflux and taking steps to prevent esophageal cancers.

Barrett’s esophagus is considered a precancerous condition and increases esophageal cancer risk. While only a small percentage of patients with Barrett’s esophagus end up developing esophageal cancer, ...

Barrett’s esophagus is a condition where the tissue in your lower esophagus becomes damaged. It starts to resemble the tissue in your intestine. Doctors call this process intestinal metaplasia. The ...

Barrett's esophagus is a premalignant lesion detected in the majority of patients with esophageal and gastroesophageal adenocarcinoma — cancers that are associated with a low rate of survival (5 ...

Barrett’s esophagus is a condition in which the tissue lining the esophagus – the tube that passes the food from the mouth to the stomach – is replaced by tissue similar to that of the ...

Barrett’s Esophagus is a condition that rarely requires surgery, but when it progresses to high-grade dysplasia or esophageal cancer, surgical intervention becomes necessary. Esophageal surgery ...

The team also developed a mouse model in which Sox2 could be selectively turned off in the esophagus. These mice showed increased cell growth, reduced cell maturation and the appearance of abnormal ...

Barrett's esophagus develops when acid and bile reflux alter the balance of transcription factors SOX2 and CDX2, shifting esophageal cells toward a stomach- or intestine-like identity.

The findings support the idea that Barrett’s esophagus may arise from the acid- and bile-triggered reprogramming of normal esophageal cells by altering the balance of SOX2 and CDX2.