San Francisco 49ers wide receiver Jauan Jennings explained his celebration after a touchdown against the Indianapolis Colts ...

The San Francisco 49ers responded to clinching a playoff spot with a 48–27 victory over the Indianapolis Colts. The ...

Skyy Moore didn't make it to the main Pro Bowl roster, but he was selected as an alternate. The strong stretch of ...

The San Francisco 49ers may have to navigate a couple of games without one of their superstars, but he avoided a longer-term ...

The San Francisco 49ers beat the Colts so thoroughly on Monday that it ruined an opposing player's Christmas plans.

Philip Rivers starts again when he takes on the ferocious 49ers on "Monday Night Football." Here's score, highlights, stats ...

The Colts' loss clinched playoff spots for the Bills and Chargers. The 49ers had already clinched their spot in the NFC, and ...

While the 49ers have won a fifth consecutive game, the Colts have now lost five straight. Here's the winners and losers from ...

The Baltimore Ravens, Denver Broncos, San Francisco 49ers and Seattle Seahawks tied for an NFL-best six selections apiece for ...

NFL Week 17 odds, picks, predictions, TV channel, streaming information for Sunday Night Football game between Chicago Bears ...

The San Francisco 49ers outlasted the Indianapolis Colts 48-27 on the road to close out Week 16 on Monday Night Football, ...

Brock Purdy was a vastly different quarterback on Monday night against the Colts compared to his prior Monday Night Football ...