There won't be many key players on the field for the San Francisco 49ers in their preseason opener vs. the Denver Broncos.

The San Francisco 49ers face the Denver Broncos in their first preseason game of the 2025 season on Saturday at 5:30 p.m. PT at Levi’s Stadium. The Niners held a joint practice with the Broncos on Thursday ahead of the preseason opener.

The San Francisco 49ers hosted the Denver Broncos for a joint training camp practice on Thursday. Fans can read a recap here and check out some of the video highlights below.

Talanoa Hufanga has playfully reconnected with former teammates during a joint practice between the Broncos and the 49ers.

The stars looked the part, with Christian McCaffrey and George Kittle making plays for the Niners, while Nix made some nice throws on the move. The 49ers didn’t mess with Broncos cornerback Patrick Surtain, the reigning NFL Defensive Player of the Year, too much in one-on-one coverage after he shut down Ricky Pearsall early.

The 49ers won’t let a slew of injuries the first two weeks of training camp stop them from hosting the Denver Broncos for Thursday’s joint practice ahead of Saturday’s preseason

Denver Broncos fans will soon get a chance to see a squad poised for a breakout year. The big picture: Denver opens their three-game preseason slate tomorrow against the San Francisco 49ers at Levi's Stadium in Santa Clara,

Kyle Shanahan has admired Bo Nix for a long time. Nothing changed with his opinion Thursday. After San Francisco and Denver took part in a joint practice at the 49ers’ facility, their head coach lauded the Broncos’ second-year quarterback from Oregon.