Hydroxyzine (whose brand names include Vistaril) and Benadryl (the brand name of diphenhydramine) are both first-generation antihistamines and share many similarities, including sedating side effects.

Hydroxyzine oral tablet is a generic drug that’s prescribed for anxiety and other conditions. Hydroxyzine has interactions with alcohol and some drugs. Examples include benzodiazepines, such as ...

Benadryl (diphenhydramine) is an over-the-counter medication for allergies and cold symptoms. Common side effects include sleepiness, dizziness, dry mouth, and indigestion. Serious side effects are ...