McCaffrey is not in line to play in Saturday's preseason opener against the Broncos, Eric Branch of the San Francisco Chronicle and David Lombardi of SFStandard.com report. With Isaac Guerendo (shoulder) and Jordan James (finger) both injured,

Christian McCaffrey, Kyren Williams, & Najee Harris have carried heavy workloads in their NFL careers. Injury concerns will raise caution in fantasy football.

The 49ers may provide an indication of how they're feeling about their RB depth in the days ahead. If they sign another veteran back out of free agency, it likely signals that Guerendo's injury may be a close call for the start of the season. They also will need enough backs just to get through preseason games in one piece, too.

Two top contenders this year face off in the preseason opener, with the San Francisco 49ers hosting the Denver Broncos. However, many fans are wondering whether stars Christian McCaffrey and Bo Nix will take the field in today's game.

Christian McCaffrey won't play in the preseason after straining his calf in Sunday's practice. He has not participated in practice since. McCaffrey, though, said his rehab is strictly precautionary. "Yeah,