Deion Sanders made his first significant change of the 2025 season by naming Ryan Staub as Colorado's starting quarterback for Friday's game against Houston over highly-touted recruit Julian Lewis.

Staub responded by leading a six-play, 75-yard drive capped by a 21-yard touchdown pass to Dekalon Taylor in just 36 seconds to give the Buffaloes a two-score advantage entering the break. Staub came back for Colorado's first drive in the third quarter and connected with wide receiver Sincere Brown for a 71-yard score.

The Colorado Buffaloes are expected to start Ryan Staub at quarterback for Friday's game at Houston, sources told ESPN.