This important study advances the HIV-1 vaccine development field by establishing six humanized immunoglobulin knock-in mouse models to facilitate the design and evaluation of HIV-1 vaccines. The ...
Neuropeptides mediate inter-tissue communication in energy metabolism, yet most remain functionally uncharacterized. Using C. elegans, we uncover a neuropeptide signaling cascade that drives lipid ...
chaining is more likely when the experiences to be integrated are relatively familiar (greater number of exposures) and ordered in a manner that promotes encoding of the associative links that are ...
We used correlative light and focussed ion beam–scanning electron microscopy (FIBSEM) to characterise the ultrastructural organisation of neuromodulatory axons in the upper layers of the adult mouse ...
The authors use a modeling approach to examine the effects of local and global perturbations on the electrophysiological properties of astrocytes: their modeling results suggest that local ionic ...
This important manuscript reports exceptionally preserved, millimeter-scale segmented bilaterian microfossils from the early Cambrian Fortunian Kuanchuanpu Formation in South China. The authors ...
This important study combines cortex-wide activity imaging and optogenetics to characterize large-scale changes in functional connectivity following administration of the psychedelic DOI, as well as ...
This important study examines the relationship between climatic niche limits and extinction risk across more than 23,000 terrestrial vertebrate species. The large comparative dataset and phylogenetic ...
The immune system relies on a number of different cells types that work together to detect and clear unwanted infections from the body. T helper cells (also known as CD4 + T cells, and hereafter ...
Protein isoforms – proteins that are similar to each other and perform similar roles within cells – have played an important role in the generation of biological diversity throughout evolution. In ...
This valuable study identifies Gcn5 as a regulator of blood cell development in the Drosophila lymph gland, with links to autophagy and nutrient-sensing mTORC1 signalling. While the mechanistic ...
The study reports on the relative lipid permeabilities of different ribonucleotide isomers. The findings are valuable for prebiotic chemistry and protocell research because they offer an additional ...
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