Childhood obesity remains a pressing global health challenge, yet the impact of dynamic adiposity changes during active developmental window retains poorly understood. Leveraging longitudinal data ...
This important study shows that neural responses to visual input during active vision are more closely aligned with self-generated eye movements than with fixation onset. The evidence for neural ...
In cancer, tumor escape often arises following treatments. This is especially true during deprivation therapies, where this phenomenon has been linked to steroid signaling reactivation despite ...
Transcranial focused ultrasound (tFUS) can modulate activity in deep brain regions non-invasively, yet its effects remain variable and incompletely understood. Because sonication deposits mechanical ...
This study presents valuable findings regarding the role of the P2X7 receptor in retinoic acid signaling-mediated retinal remodeling following photoreceptor degeneration. However, the evidence ...
Brain organoids, also known as brain spheroids, are three-dimensional cultures of neural cells derived from pluripotent stem cells (PSCs) that mimic the brain’s organization, development, and activity ...
Science is better when we publish according to our values! Most publishing models act as a barrier, rather than a medium, between authors and audiences; eLife feels like the opposite.
Mas-Related GPCR X4 (MRGPRX4) is a sensory neuron-restricted receptor for cholestatic itch. Here, we identify MRGPRX4 as an unexpected melanoma driver. MRGPRX4 is upregulated in melanoma and is ...
A family of proteins called Toll receptors, best known for their role in the immune system, also enable the brain to change its structure in response to experience. Everything that you experience ...
The CRISPR-Cas system in some bacteria helps to form an effective barrier to invading viruses. Just as humans are susceptible to viruses, bacteria have their own viruses to contend with. These viruses ...
A new method enables engineered immune progenitor cells to replace microglia in mice and reveals how a genetic mutation can lead to inflammation in the brain.
The autobiographical memory deficits seen in aphantasia are reflected by altered activation and connectivity patterns of the hippocampus and occipital cortex, corroborating the strong link between ...
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