A previously healthy 23-year-old woman presented with an 11-month history of foot pain and difficulty walking. Neurologic examination showed the left foot fixed in plantar flexion and inversion ...

A primary care physician, stumped by a patient’s chronic condition, turns to AI for a diagnosis and treatment recommendation — but discovers the essential role that must still be played by a human ...

Early cardiopulmonary resuscitation (CPR) and defibrillation improve survival after out-of-hospital cardiac arrest, but ...

For patients with moderate aortic stenosis, current guidelines recommend clinical surveillance with echocardiographic assessment every 1 or 2 years. Whether transcatheter aortic-valve replacement ...

Angiopoietin-like protein 4 (ANGPTL4) inhibits lipoprotein lipase and regulates triglyceride-rich lipoprotein metabolism. MAR001 is a monoclonal antibody against ANGPTL4 that is being evaluated for ...

Corporations that make and market health-harming products are a primary vector for the global increase in mortality related to noncommunicable diseases. Research using internal industry documents c ...

Retatrutide, an investigational triple agonist of GIP, GLP-1, and glucagon receptors, may be useful for the treatment of painful knee osteoarthritis in persons with obesity. In two phase 3 trials, ...

In patients with refractory out-of-hospital cardiac arrest, extracorporeal cardiopulmonary resuscitation (ECPR) with the use of venoarterial extracorporeal membrane oxygenation can be performed to ...

Obesity is the most common chronic disease in the world.1 Even more devastating are its sequelae, which range from sleep apnea and osteoarthritis to an increased risk of cardiovascular disorders, ...

It has taken a long time to move extracorporeal cardiopulmonary resuscitation (ECPR) from a method used for late rescue of patients in cardiac arrest toward one used for earlier reperfusion. The ...

In three patients with refractory epilepsy, hippocampal chemogenetic therapy plus low-dose clozapine was associated with a mean seizure-frequency reduction of 92.6%. Adverse events were grade 1 or 2.