BMJ

Infections and the risk of incident giant cell arteritis: a population-based, case-control study

Objectives Alterations in the immune system and infections are suspected to increase susceptibility to giant cell arteritis (GCA). Recently herpes zoster has been directly implicated in the ...
BMJ

Global, regional and national burden of osteoarthritis 1990-2017: a systematic analysis of the Global Burden of Disease Study 2017

Objectives To report the level and trends of prevalence, incidence and years lived with disability (YLDs) for osteoarthritis (OA) in 195 countries and territories from 1990 to 2017 by age, sex and ...
BMJ

Thickness of human articular cartilage in joints of the lower limb

OBJECTIVES (a) To determine the topographical variations in cartilage thickness over the entire surfaces of cadaveric lower limb joints, and (b) to examine the correlations between: cartilage ...
BMJ

The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part I): classification of paper patients by ...

Rheumatology, Med Klinik I, Charité, Campus Benjamin Franklin, Berlin, Germany ...
BMJ

FOXP3 expression in blood, synovial fluid and synovial tissue during inflammatory arthritis and intra-articular corticosteroid treatment

Objective: To analyse the distribution of FOXP3+CD25+CD4+ regulatory T cells (Treg) in peripheral blood, synovial fluid and tissue of patients with rheumatic disease during relapse and after local ...
BMJ

PUF60: a prominent new target of the autoimmune response in dermatomyositis and Sjögren's syndrome

Objectives Autoantibodies are used clinically to phenotype and subset patients with autoimmune rheumatic diseases. We detected a novel 60 kDa autoantibody specificity by immunoblotting using a ...
BMJ

Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation

1 Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne, UK 2 Department of Rheumatology, Medical School, Newcastle University, Newcastle upon Tyne, UK 3 Department ...
BMJ

The cathelicidins LL-37 and rCRAMP are associated with pathogenic events of arthritis in humans and rats

3 Rheumatology Unit, Department of Medicine at the Karolinska University Hospital Solna, Sweden 4 Division of Rheumatology, Department of Internal Medicine 3, Medical University of Vienna, Vienna, ...
BMJ

Moderate vitamin D deficiency is associated with changes in knee and hip pain in older adults: a 5-year longitudinal study

Background Vitamin D is important for bone, cartilage and muscle function but there are few studies on its association with joint pain. Objective To investigate whether serum vitamin D predicts change ...
BMJ

Th1 but not Th17 cells predominate in the joints of patients with rheumatoid arthritis

Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan H Yamada, Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, 3-1 ...
BMJ

Inflammation in ankylosing spondylitis: a systematic description of the extent and frequency of acute spinal changes using magnetic resonance imaging

Background: Magnetic resonance imaging (MRI) is increasingly used to detect inflammation in the spine of patients with ankylosing spondylitis (AS). Objectives: To detect differentially the presence ...
BMJ

Role of RANKL and RANK in bone loss and arthritis

1 Institute for Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria Departments of Immunology and Medical Biophysics, University of Toronto, University Health Network, Canada ...