BMJ

Disease activity drives divergent epigenetic and transcriptomic reprogramming of monocyte subpopulations in systemic lupus erythematosus

Objectives Systemic lupus erythematosus (SLE) is characterised by systemic inflammation involving various immune cell types. Monocytes, pivotal in promoting and regulating inflammation in SLE, ...
BMJ

Central nervous system involvement in Sjögren’s syndrome

Department of Pathophysiology, School of Medicine, National University of Athens, Greece Correspondence to: Professor H M Moutsopoulos Department of Pathophysiology, Medical School, University of ...
BMJ

DNA methylome signature in rheumatoid arthritis

1 Department of Medicine, University of California San Diego School of Medicine, La Jolla, California, USA 2 Department of Chemistry and Biochemistry, University of California San Diego School of ...
BMJ

Gastric antral vascular ectasia in systemic sclerosis: complete resolution with methylprednisolone and cyclophosphamide

Dr A Gough, Department of Rheumatology, Harrogate District Hospital, Lancaster Road, Harrogate HG2 7SX, UK A case of severe, transfusion dependent anaemia in a 72 year old woman, which on endoscopy ...
BMJ

Cutaneous adverse events with febuxostat after previous reactions to allopurinol: comment on the article by Singh and Cleveland

We read with interest the recent article by Singh and Cleveland on the hypersensitivity risk of allopurinol (ALP) and febuxostat (FBX) compared with colchicine.1 A common challenge when using ALP, ...
BMJ

Is a 1-year course of methotrexate in patients with arthralgia at-risk for rheumatoid arthritis cost-effective? A cost-effectiveness analysis of the randomised, placebo ...

Objectives Rheumatoid arthritis (RA) has a considerable disease burden with life-long physical limitations, reduced work productivity and high societal costs. Trials on arthralgia at-risk for RA are ...
BMJ

Real-life use of the PEXIVAS reduced-dose glucocorticoid regimen in granulomatosis with polyangiitis and microscopic polyangiitis

3 Centre de Recherche en Epidémiologie et Statistiques (CRESS), Unité Inserm 1153, Université Paris Cité, Paris, France ...
BMJ

Relationship between serum urate and changes in dual-energy CT monosodium urate crystal volume over 1 year in people with gout: an individual participant data analysis

Objectives The dynamics of monosodium urate (MSU) crystal changes across a range of serum urate concentrations in people with gout are unknown. This study aimed to systematically examine the ...
BMJ

Peripheral blood immunophenotypic diversity in patients with rheumatoid arthritis and its impact on therapeutic responsiveness

Objective Considering the diverse aetiologies and immunodysregulatory statuses observed in each patient with rheumatoid arthritis (RA), stratification based on peripheral blood immunophenotyping holds ...
BMJ

Primary Sjögren's syndrome and malignancy risk: a systematic review and meta-analysis

Department of Laboratory Diagnostics, Changzheng Hospital, Second Military Medical University, Shanghai, China Correspondence to Dr Yang Zaixing and Professor Renqian Zhong, Department of Laboratory ...
BMJ

Evidence that autoantibody production may be driven by acute Epstein-Barr virus infection in Sjögren’s disease

Objectives Sjögren’s disease (SD) is an autoimmune disease affecting the exocrine glands that is associated with autoantibodies against Ro60/SS-A, anti-Ro52/TRIM21, La/SS-B and others. We examined the ...
BMJ

Antibodies to native and citrullinated RA33 (hnRNP A2/B1) challenge citrullination as the inciting principle underlying loss of tolerance in rheumatoid arthritis

Background Anti-citrullinated protein antibodies (ACPAs) are the hallmark of rheumatoid arthritis (RA). Protein citrullination is believed to drive autoantigen selection in RA. Nonetheless, several ...