San Francisco 49ers quarterback Brock Purdy threw five touchdowns against the Indianapolis Colts on Monday, earning NFC Offensive Player of the Week.

Two Columbus sisters say they were threatened after following vehicles they believed belonged to ICE, an act that is not ...

The San Francisco 49ers may have to navigate a couple of games without one of their superstars, but he avoided a longer-term ...

Week 16 was a great week for the San Francisco 49ers, who clinched a playoff berth and moved up in both the division and ...

The 49ers may have offensive tackle Trent Williams around for longer than expected after his comments following their win ...

A Florida Powerball ticket is worth $1 million. Another winner in Dec. 22 drawing is a Fantasy 5 ticket sold in Vero Beach.

The San Francisco 49ers had six players make the NFC roster for the 2026 Pro Bowl Games, but one more should've been there.

The FBI has assumed the search for two missing boaters, one from Fort Myers and one from Boca Raton, as a federal missing persons case.

The San Francisco 49ers offense is cruising and they were dominant in a win over the Indianapolis Colts. Here are the ...

The San Francisco 49ers downed the Indianapolis Colts on Monday night, and here's who deserves credit and criticism.

The San Francisco 49ers have had a strong showing in 2025, leading to _ of their players getting selected to the 2026 Pro ...

The San Francisco 49ers beat the Indianapolis Colts on Monday. How did their performance affect their standing heading into ...