Explore this issue of The New England Journal of Medicine (Vol. 394 No. 10).

Once-daily, single-tablet regimens have transformed care for persons living with human immunodeficiency virus type 1 (HIV-1); ...

This study supports enzymatic cross-correction of neurons and oligodendrocytes by atidarsagene autotemcel, a gene therapy ...

Langley et al. (April 23 issue)1 make a strong case for using transdermal estradiol (tE2) for androgen-deprivation therapy. However, gynecomastia is a common side effect of ...

A 45-year-old man presented with a 2-month history of worsening pain and swelling in his right shoulder. A radiograph showed destruction of the humeral head with a free-floating humeral diaphysis.

In 832 patients with rare genetic disease, a conclusive diagnosis was made for 160 patients (19.2%) with long-read genome sequencing and for 137 patients (16.5%) with standard-of-care testing.

When a physician’s own incidental finding sends her down a long and winding path to find answers, she finds herself overcome with worry — but also, eventually, a new appreciation for life.

Supported by a grant (TTU 08.711, to Christoph M. Ernst) from the German Center for Infection Research (DZIF), by a gift from A. and J. Bekenstein (to Deborah T. Hung), and by a grant (U19AI110818, to ...

A 51-year-old woman with right heart failure presented with worsening abdominal distention and leg swelling. Examination was notable for ascites, leg edema, a grade 4/6 holosystolic murmur, and a ...

Personalized therapies hold tremendous promise but challenge traditional models of drug and biologic development. The FDA outlines a path to market entry for products where a randomized trial is no ...

Explore this issue of The New England Journal of Medicine (Vol. 395 No. 4).