The treatment of advanced prostate cancer has undergone significant improvements, with two developments proven to be especially transformative. The first advance was the establishment of treatment ...

The efficacy of teclistamab, a bispecific antibody targeting B-cell maturation antigen and CD3, as early-line monotherapy in relapsed or refractory multiple myeloma is unclear. We randomly ...

The most important attribute of patient-centered care is the active engagement of patients when fateful health care decisions must be made — when they arrive at a crossroads of medical options, where ...

Two phase 3, randomized trials of inhaled treprostinil for idiopathic pulmonary fibrosis (IPF) were conducted on the basis of preclinical and clinical evidence of an antifibrotic mechanism.

Protective variants of genetic loci are of particular interest for two reasons: first, because they are important from a clinical genetic perspective; and second, because they may give mechanistic ...

Blood transfusion before arrival at a hospital reduces mortality from traumatic hemorrhage and shock. Whether transfusion with whole blood is more beneficial than transfusion with blood components ...

Wheezing illnesses are a leading cause of hospitalization for preschool-age children and are frequently treated with antibiotics. Observational studies have shown more frequent isolation of three ...

Since social problems affect health and treatment effectiveness, considering them in assessments and treatment plans should improve outcomes, reduce costs, and improve patient satisfaction. How sho ...

A virtual consultation was held on May 2 with medical specialists from South Africa, the United Kingdom, and Holland to discuss the potential link to two recent fatalities associated with the same ...

Large B-cell lymphoma is a spectrum of aggressive B-cell cancers with broad genetic and clinical heterogeneity. 1 First-line chemotherapy cures most patients, but those with relapsed or refractory ...

Explore this issue of The New England Journal of Medicine (Vol. 386 No. 21).