Early cardiopulmonary resuscitation (CPR) and defibrillation improve survival after out-of-hospital cardiac arrest, but ...

Retatrutide, an investigational triple agonist of GIP, GLP-1, and glucagon receptors, may be useful for the treatment of painful knee osteoarthritis in persons with obesity. In two phase 3 trials, ...

For patients with moderate aortic stenosis, current guidelines recommend clinical surveillance with echocardiographic assessment every 1 or 2 years. Whether transcatheter aortic-valve replacement ...

Obesity is the most common chronic disease in the world.1 Even more devastating are its sequelae, which range from sleep apnea and osteoarthritis to an increased risk of cardiovascular disorders, ...

The U.S. health care system still can’t identify medical harm as it occurs. But it’s now possible to develop systems that correct their own deficiencies and make improvements that matter to patients.

Savolitinib is an oral, potent, highly selective MET–tyrosine kinase inhibitor (TKI). Combination therapy with savolitinib and osimertinib, an epidermal growth factor receptor (EGFR)–TKI, has shown ...

Explore this issue of The New England Journal of Medicine (Vol. 393 No. 20).

Multiple myeloma has undergone a therapeutic revolution at a pace nearly unmatched in oncology. Yet amid these advances, a key assumption in multiple myeloma therapy persists: more and longer ...

Pembrolizumab plus chemotherapy with a platinum-based agent and pemetrexed is a widely used standard first-line treatment option for patients with programmed death ligand 1 (PD-L1)–negative advanced ...

When patients, or the parents of patients, become heavily invested in searching for someone to blame for an illness, it’s useful to ask what the search is doing for them. Its accuracy is rarely ...

In adults with symptomatic severe aortic stenosis, aortic-valve replacement (AVR) relieves symptoms and improves survival. 1-3 Over the past 20 years, more information about the progression of aortic ...