More evidence is needed to inform recommendations for intervals of colonoscopy surveillance after polyp removal. In this ...

Many patients with chronic obstructive pulmonary disease (COPD) have exacerbations despite receiving standard-of-care inhaled ...

Tambotatug pelitecan (known as Tam-Peli, a new antibody–drug conjugate that targets the immune-checkpoint molecule B7-H3) showed promising clinical efficacy in patients with relapsed extensive-stage ...

A 65-year-old man was admitted to this hospital because of fever, intermittent abdominal pain, and rash. The fever began 5 weeks earlier, and palpable purpura developed 1 week before admission. A ...

Trichodysplasia spinulosa–associated polyomavirus was identified as a likely cause of neuroinvasive infection in a ...

A 3-year-old boy with chemotherapy-resistant metastatic hepatoblastoma had complete regression lasting at least 12 months after two infusions of glypican-3–specific CAR T cells coexpressing ...

Explore this issue of The New England Journal of Medicine (Vol. 394 No. 4).

The Indian Health Service has limited options for recruiting physicians to its most understaffed sites. Partnerships with academic medical centers could help address long-standing physician shortages.

A 72-year-old man with hypertension, hyperlipidemia, and a stable ascending aortic aneurysm presented with sudden-onset, ...

Progress against the U.S. HIV epidemic is stalling, owing in part to government attacks and fear. But clinicians, patients, and activists can learn from the epidemic’s early heroes and find ways ...

Treatment of the left main coronary artery with percutaneous coronary intervention (PCI) in the absence of previous surgical revascularization, also referred to as an unprotected left main coronary ...