When a patient receives a diagnosis of amyotrophic lateral sclerosis, he is shocked. But he’s also dubious enough to seek a second opinion.

A 51-year-old woman with right heart failure presented with worsening abdominal distention and leg swelling. Examination was notable for ascites, leg edema, a grade 4/6 holosystolic murmur, and a ...

As legislative support for medical aid in dying grows, the paradox at the heart of this option, with its broader-than-expected benefits, becomes increasingly clear: its expansion hinges on its rarity.

In this phase 3b, open-label, controlled trial, adult participants with obesity but without type 2 diabetes were randomly assigned in a 1:1 ratio to receive the maximum tolerated dose of tirzepatide ...

Andes virus (ANDV) is the sole orthohantavirus with documented human-to-human transmission. We summarize the epidemiology and clinical features of ANDV infection and review best practices in clinical ...

Explore the current issue of The New England Journal of Medicine (Vol. 395 No. 3).

Explore this issue of The New England Journal of Medicine (Vol. 392 No. 5).

The United States could take meaningful steps toward eliminating hepatitis C by broadly testing and treating people who are involved in the criminal legal system.

Explore this issue of The New England Journal of Medicine (Vol. 392 No. 3).

Regulations give substantial discretion to individual organizations when it comes to sharing deidentified data and specimens with outside entities. Academic medical centers are practically and ...

Sarcoidosis, a granulomatous disease that affects the lungs and other organs, has a variable course. Although spontaneous resolution of sarcoidosis occurs in some patients, half the patients with ...

Multiple myeloma has undergone a therapeutic revolution at a pace nearly unmatched in oncology. Yet amid these advances, a key assumption in multiple myeloma therapy persists: more and longer ...