Guidelines recommend a trial of antiarrhythmic drugs before catheter ablation for persistent atrial fibrillation. Whether pulsed field ablation (PFA) may be a preferred initial treatment is ...

Blood-pressure reduction is the only proven treatment to prevent stroke. Whether a single pill that combines three ...

There has been substantial interest in the development of GLP-1 drugs and optimism about their public health effects. But some worrisome signals related to disordered eating have emerged.

Whether treatment with balanced crystalloid fluid leads to better outcomes than 0.9% saline in children treated for septic ...

A physician offers to help in a medical emergency on a transatlantic flight. Though she faces limits of bureaucracy, equipment, and ultimately biology, she discovers her physicianhood is inescapable.

Explore this issue of The New England Journal of Medicine (Vol. 390 No. 10).

A 60-year-old woman with follicular lymphoma was evaluated for swelling and proteinuria that had persisted for 2 weeks. The patient’s plasma was clear at 37°C but turbid at 4°C. A kidney ...

Explore this issue of The New England Journal of Medicine (Vol. 394 No. 8).

Explore this issue of The New England Journal of Medicine (Vol. 390 No. 9).

Explore this issue of The New England Journal of Medicine (Vol. 391 No. 16).

Explore this issue of The New England Journal of Medicine (Vol. 391 No. 17).

Overactivation of the alternative complement pathway contributes to IgA nephropathy and glomerular inflammation. In the 9-month interim analysis of this phase 3 trial, iptacopan, a complement factor B ...