Two phase 3, randomized trials of inhaled treprostinil for idiopathic pulmonary fibrosis (IPF) were conducted on the basis of preclinical and clinical evidence of an antifibrotic mechanism.

Blood transfusion before arrival at a hospital reduces mortality from traumatic hemorrhage and shock. Whether transfusion with whole blood is more beneficial than transfusion with blood components ...

Wheezing illnesses are a leading cause of hospitalization for preschool-age children and are frequently treated with antibiotics. Observational studies have shown more frequent isolation of three ...

Recombinant adeno-associated virus (AAV) vectors are predominantly nonintegrating, but rare genomic integration events have been associated with oncogenesis in neonatal murine models. Here we ...

Avian influenza can jump species from birds to humans, a fact that arouses concern for serious illness and broader human ...

A 50-year-old woman was admitted to the hospital because of vaginal bleeding and anemia. She had a history of fibroids and 1 ...

Clinicians are rightly expected to disclose their gaps in knowledge or their inability to forecast an outcome. Yet emerging AI tools often cannot, or will not, do the same.

This Sounding Board announces a new FDA policy that the default requirement for FDA approvals will be one robust pivotal trial plus confirmatory evidence, rather than two trials.

The dismantling of foreign-assistance efforts has already had, and will continue to have, severe effects on vulnerable populations globally. But it also has implications for people in the United St ...

Today, the covenant between U.S. academic medical centers and society is under strain: corporatization and the mandate to ...

Explore this issue of The New England Journal of Medicine (Vol. 392 No. 18).

A 32-year-old man presented with recurrent dysphagia caused by food impaction. Endoscopy revealed trachealization of the esophagus, and a diagnosis of eosinophilic esophagitis was made.