The U.S. health care system still can’t identify medical harm as it occurs. But it’s now possible to develop systems that correct their own deficiencies and make improvements that matter to patients.

When patients, or the parents of patients, become heavily invested in searching for someone to blame for an illness, it’s useful to ask what the search is doing for them. Its accuracy is rarely ...

Explore this issue of The New England Journal of Medicine (Vol. 394 No. 12).

Whether endovascular therapy benefits patients with mild acute ischemic stroke from large-vessel occlusion involving the ...

Explore this issue of The New England Journal of Medicine (Vol. 393 No. 20).

A 3-year-old boy with chemotherapy-resistant metastatic hepatoblastoma had complete regression lasting at least 12 months after two infusions of glypican-3–specific CAR T cells coexpressing interle ...

A 36-year-old woman presented with a 6-year history of gradually worsening low back pain and intermittent night sweats. On examination, she had a sharp, kyphotic angulation of the lower spine.

Agencies have long relied on civil monetary penalties to address violations of health care and public health regulations. But rules governing federal fines are now in flux.

Savolitinib is an oral, potent, highly selective MET–tyrosine kinase inhibitor (TKI). Combination therapy with savolitinib and osimertinib, an epidermal growth factor receptor (EGFR)–TKI, has shown ...

To improve the quality of observational studies, target trial emulation requires careful specification of design elements, analytic methods for addressing confounding, and reporting of sensitivity ...

Explore this issue of The New England Journal of Medicine (Vol. 390 No. 1).

Clinicians in Puerto Rico sometimes provide abortion care to people who travel to obtain services that are no longer provided in their home states. Yet residents themselves face high barriers to care.