The author describes the scientific foundations and implications of the results of a randomized, controlled trial of Mim8, a new mimetic of factor VIIIa, to treat hemophilia A.

A 76-year-old woman, who had a history of treated hepatitis C virus infection, presented with rapidly progressive kidney failure and a stroke. Palpable purpura on the legs was noted. A diagnosis ...

Guidelines recommend a trial of antiarrhythmic drugs before catheter ablation for persistent atrial fibrillation. Whether pulsed field ablation (PFA) may be a preferred initial treatment is ...

Blood-pressure reduction is the only proven treatment to prevent stroke. Whether a single pill that combines three ...

Drug-overdose deaths among adolescents have increased in recent years. Steps can be taken to equip adolescents with the knowledge and tools they need to keep themselves safe.

Explore this issue of The New England Journal of Medicine (Vol. 394 No. 3).

Whether treatment with balanced crystalloid fluid leads to better outcomes than 0.9% saline in children treated for septic ...

There has been substantial interest in the development of GLP-1 drugs and optimism about their public health effects. But some worrisome signals related to disordered eating have emerged.

The resident presented a patient admitted for chest pain after walking his dog. The attending asked, “What was the name of his dog?” The resident was stumped. Four years later, he’s not sure anythi ...

The Pediatric Research Equity Act was intended to promote the development and testing of prescription drugs for children. But ...

Explore this issue of The New England Journal of Medicine (Vol. 390 No. 10).

Explore this issue of The New England Journal of Medicine (Vol. 394 No. 8).