The Tampa Bay Rays hit the road against the Pittsburgh Pirates aiming to continue a five-game road winning streak.
The Chicago White Sox aim to stop their three-game losing streak with a victory over the Athletics.
The San Diego Padres will attempt to build upon an eight-game win streak with a victory over the Los Angeles Angels.
The Kansas City Royals head into the matchup against the New York Yankees after losing four games in a row.
The Arizona Diamondbacks host the Toronto Blue Jays to begin a three-game series.
The Detroit Tigers hit the road against the Boston Red Sox looking to stop an eight-game road losing streak.
The New York Mets will look to stop their three-game road losing streak in a matchup with the Chicago Cubs.
The Seattle Mariners look to break their three-game skid when they take on the Texas Rangers.
The Houston Astros host the St. Louis Cardinals to start a three-game series.
The Minnesota Twins host the Cincinnati Reds to start a three-game series.
San Francisco Giants (7-12, fifth in the NL West) vs. Washington Nationals (9-10, third in the NL East) ...
The Colorado Rockies host the Los Angeles Dodgers to open a four-game series.