A small Mexican Navy plane transporting a young medical patient and seven others crashed Monday near Galveston, killing at least five people and setting off a search in waters along the Texas coast, ...

Kansas could lure the Chiefs from Missouri with a $2B stadium plan as lawmakers vote Monday on STAR bonds covering up to 70% ...

Physician’s Park pharmacy to stay open as John’s Pharmacy adds a second Poplar Bluff location amid Missouri Highlands’ ...

Cape Girardeau man accused of breaking in, stabbing victim and holding six children hostage at knifepoint now jailed without ...

Sikeston and Puxico set up an unbeaten showdown as holiday tournaments tip off and new contenders surge in this week’s ...

Red Sox land 3-time All-Star Willson Contreras from Cardinals, sending injured righty Hunter Dobbins and two Single-A ...

Readers unleash a barrage of sharply divided opinions on Trump, Epstein files, presidential libraries, domestic violence laws ...

Scott City erased Woodland’s three-quarter lead behind Skylar Watson’s 18 points and clutch 3s, handing the Cardinals a 45-42 home heartbreak.

Alex Holmes, assistant manager for the Missouri Department of Conservation’s Cape Girardeau Conservation Nature Center, shares opportunities for you to get involved in communal science projects this ...

Asian shares were mostly higher on Tuesday after benchmarks on Wall Street rose at the start of what’s expected to be a relatively calm holiday week.

KANSAS CITY, Mo. (AP) — The state of Missouri is losing its third NFL franchise and the second in the past decade, and the decision by the Chiefs on Monday to depart their longtime home at Arrowhead ...

Holiday upsets shake up the Semoball girls basketball Top 10 as Jackson edges St. Vincent for No. 1, Doniphan stays perfect and Notre Dame charges into the rankings.