This article explores how advances in antibody engineering are moving immunotherapy beyond traditional monoclonal antibodies to bispecific and trispecific formats and logic-gated designs.

Researchers showed how tandem kinase immune receptors recognize blast fungus effectors and engineered them to detect effectors from wheat and barley infections, opening a path toward broader, more ...

Researchers investigated neuromuscular junction function in aging and found that NaV1.4 loss impaired nerve-muscle communication. In animal models, ClC-1 inhibition improved muscle responsiveness and ...

This listicle explores six analytical approaches shaping modern PFAS monitoring, highlighting their strengths, applications, ...

A global analysis of 58,318 outbreaks found that environmental drivers of emerging diseases vary by pathogen, while fragmented ecosystems raise risks for some infections. Limited healthcare access ...

Researchers traced cells during early development and identified distinct progenitors for the forebrain and midbrain vs the ...

Researchers analyzed gene expression across 17 autism-linked mouse lines and found two opposing molecular states, suggesting diverse risk mutations can converge on shared brain biology.

Researchers compared human and marmoset brain organoids and found differences in neural progenitor cell structure, division, and timing that reduced neuron production, helping explain the marmoset's ...

Researchers developed NUDGE, a computational framework that identifies minimal, temporary interventions for guiding cells toward desired states while preserving cellular plasticity.

Human cells exposed to simulated microgravity showed increased nuclear volume, while genome organization remained stable and no DNA damage occurred.

An AI model has been developed to predict the most stable form of drug-like molecules by identifying hydrogen atom positions. The tool could improve molecular modeling, drug screening, and ...

A study found that chronic stress increased bladder sensitivity and urinary frequency by promoting oxidative damage, inflammation, and barrier disruption. Exercise was found to modulate these changes ...