INDIANAPOLIS (WISH) — The Colts lost to the 49ers, 48-27. The loss dropped the team’s record to 8-7 and marked their fifth ...

The loss drops the Colts to 8-7, and it is their fifth straight loss. The Colts trailed 24-17 at halftime. Next up for the ...

Colts trail 49ers 24-17 at halftime. Philip Rivers threw 2 TDs, but the Colts defense struggles. 49ers to receive the ball in ...

Chemical explosion at The Heritage Group in Indianapolis leaves one person seriously injured. Firefighters working to ...

Jaylen Brown's 31-point performance leads Boston Celtics to a comeback victory over Indiana Pacers. Celtics win their third ...

U.S. military strike on alleged drug boat in Pacific Ocean kills one. Operation Southern Spear aims to curb narcotics ...

Georgia Street Rhythm & Blues Lounge in Indianapolis now restricts entry to those 30 and older, aiming to create a more ...

Novo Nordisk's weight-loss pill, Wegovy, has been approved by the FDA, giving the company a competitive edge in the market ...

At least four people are dead after a Mexican Naval plane carrying burn patients crashed into Galveston Bay in Texas on ...

Carmel man charged in road rage incident on I-465 that led to a report of shots fired. Thomas Wayne Ferguson faces multiple ...

Fatal two-car crash on Indianapolis' east side results in one death. Investigation suggests possible medical issue prior to ...