President Donald Trump on Sunday said the U.S. Navy would “immediately” begin a blockade to stop ships from entering or ...

An English manufacturer plans to invest nearly $3 million in expanding and modernizing its plant in Chautauqua County. Renold ...

Buffalo police respond to scene on Deerfield Avenue early Sunday morning.

On World Parkinson’s Day, doctors are highlighting a growing need for awareness of the disease, including how to detect early ...

The Sabres have stacked up 106 points and sit among the Eastern Conference's best, but there’s one part of their game that’s ...

The Sabres have stacked up 106 points and sit among the Eastern Conference's best, but there’s one part of their game that’s ...

Artists created portraits right in front of you. People could choose from a quick caricature or a full one-hour piece.

Kyle Denhardt was taken into custody after an incident on White Street that prompted a shelter-in-place order.

Buffalo Police are investigating an early morning shooting after a women had been shot in the leg.

2 On Your Side takes a closer look at World Parkinson's Day and Black Maternal Health Week.

29-year-old Brandon Bott is accused of shooting a 36-year-old man on Bogardus Street last month.

More than a million Americans are impacted by Parkinson's Disease. Doctors say recognizing early symptoms can make a ...