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The San Diego Padres face the St. Louis Cardinals in the opener of a 4-game set at Busch Stadium in St. Louis Thursday.

The Arizona Diamondbacks lost to the San Diego Padres 4-3 on July 10, 2025, despite a good showing from their bullpen.

BOTTOM LINE: The Arizona Diamondbacks take a 2-1 lead into the next game of the series against the San Diego Padres. San Diego is 28-17 at home and 49-43 overall.

The Arizona Diamondbacks lost to the San Diego Padres 4-3 on July 10, 2025, despite a good showing from their bullpen.

Diamondbacks starter Brandon Pfaadt, since May 20, has one win, three losses and four no-decisions. His last win was June 10.

Arizona State football's Kenny Dillingham makes 2025 Dodd Trophy watch list Arizona Diamondbacks vs. San Diego Padres: Game time, pitching matchups and more What direction are Diamondbacks leaning ...

View news about the Arizona Diamondbacks vs. San Diego Padres game played on July 10, 2025 including player news, injury news, predictions, analysis and more.

San Diego has gone 28-16 at home and 49-42 overall. Padres hitters are batting a collective .245, which ranks 10th in the NL. Arizona has a 22-22 record in road games and a 45-47 record overall.

The Arizona Diamondbacks lost 1-0 to the San Diego Padres on July 8, leaving nine runners on base.