Highlights from the Week 16 matchup between the San Francisco 49ers and the Indianapolis Colts during the 2025 NFL season.
San Francisco 49ers defensive tackle Alfred Collins sacks Indianapolis Colts quarterback Philip Rivers, who fumbles the ball that is recovered by the Colts 5-yard line.
San Francisco 49ers running back Christian McCaffery catches a 9-yard touchdown pass from quarterback Brock Purdy.
San Francisco 49ers quarterback Brock Purdy completes a 17-yard pass to wide receiver Jauan Jennings. Indianapolis Colts ...
Indianapolis Colts cornerback Camryn Bynum takes advantage of the missed catch by San Francisco 49ers wide receiver Kendrick ...
Indianapolis Colts quarterback Philip Rivers completes a 19-yard pass to tight end Tyler Warren. San Francisco 49ers ...
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