This article was previously published with some errors. There was a discrepancy between the abstract and the full text regarding the number of patients on continuous hydroxychloroquine therapy over 5 ...

Background The B cell-activating factor (BAFF) promotes the maturation, differentiation, and survival of B lymphocytes, which play an important role in the pathogenesis of systemic lupus erythematosus ...

Bone involvement is a common cause of morbidity and disability in systemic lupus erythematosus (SLE). 1 This is both a consequence of the disease itself and treatments, including steroids.2 As ...

A key lupus outcome measure is the assessment of damage, which is considered as a separate domain to disease activity and health related quality of life and has been shown to independently predict ...

Hemophagocytic lymphohistiocytosis (HLH) is a well-recognised complication of systemic lupus erythematosus (SLE). In one small case series, HLH was noted in approximately 5% of patients with lupus. 1 ...

The British Isles Lupus Assessment Group (BILAG)-2004 index is a comprehensive disease activity instrument for systemic lupus erythematosus (SLE). 1 Its key advantages are the ability to capture rare ...

Systemic lupus erythematosus (SLE) is a clinically and immunologically heterogeneous autoimmune disease that can be challenging to diagnose, especially in its early stages. Although developed in the ...

Conclusions We report substantial differences in lupus nephritis mortality rates by sex, age, geographic region, urbanization level, and race/ethnicity. This study suggests strong, independent and ...

Background/ Purpose Systemic lupus erythematosus (SLE) is a chronic autoimmune disease in which clinical symptoms and laboratory measurements are heterogeneous across patients. 1 2 Such clinical ...

Background/ Purpose We recently showed that in SLE, IL-4 suppressed the development of interferon-beta (IFNβ) and TLR7-stimulated T-bet + double negative 2 (DN2) B cells. Here we investigate the ...

Background/ Purpose Nephritis is one of the most severe manifestations in lupus, affecting 40–70% of patients. Though immune targeted therapies have improved, a significant number of patients ...

Objective BAFF and APRIL signal through TACI, BCMA, and/or BAFF-R, and play important roles in the activation, differentiation, and/or survival of B cells, particularly antibody-secreting cells, as ...