Background: Cardiovascular disease (CVD) is a leading cause of morbidity and mortality in systemic lupus erythematosus (SLE). 1 Patients with SLE have a 2- to 10-fold higher risk of ischemic heart ...

Objectives To analyse the response to immunosuppressants (IS) in extrarenal flares of SLE to determine the most appropriate timing during follow-up for a change in therapeutic strategy.Methods ...

In comparison to oncologists, rheumatologists have been slow to begin using combinations of drugs in the treatment of the conditions they manage. The most widely used biologic drugs in patients with ...

Background/ Purpose Mental health (MH) problems are prevalent in adolescents with childhood-onset lupus (cSLE), with cross-sectional studies estimating prevalences of 20-60% for depression symptoms ...

Background Young adulthood, 18–30 years, is a time when many individuals start working. Failing to establish employment during young adulthood could predict lifetime financial hardships. Lack or ...

Case 1. A young female with erosive arthritis and SLE A Caucasian female patient was diagnosed with systemic lupus erythematosus (SLE) at the age of 18 years due to malar rash, arthralgias, alopecia, ...

Background Breakdown of the blood-brain barrier (BBB) integrity is required for the development of psychiatric manifestations in SLE (NPSLE), especially in lupus psychosis for the direct attack by ...

Background Mechanisms for SLE-mediated cognitive impairment (SLE-CI) include autoantibodies and inflammatory molecules normally excluded from the brain by an intact blood brain barrier (BBB). However, ...

Conclusion Our data show that during initial interactions between antigen-primed, autoreactive T and B cells, a threshold of B cell costimulatory signals is required for T cell activation and ...

Background Adverse childhood experiences (ACEs) have been linked to poorer adult health outcomes. ACEs may be a risk factor for heightened disease activity among Black American women living with ...

Background Low-dose IL-2 supplementation is a promising treatment of SLE. However, in most of current studies, lack of appropriate control groups lead to uncertainty on its efficacy. We conducted a ...