The breakaway City Council members showed they’re not ready to concede ground to Mayor Brandon Johnson and his allies over how to implement their budget plan.

One of the few federal agencies headquartered outside of Washington D.C. is nearing a deal to move its main office to the Loop.

The Chicago startup sold its original business and is now building software, payment systems and AI tools for Asian restaurants.

A home built in 1968 in Barrington puts the glass-wrapped great room one flight above the ground, closer to the trees.

Instead, the Chicago Department of Aviation wants the FAA to keep flights at current levels and support its plan to speed up a terminal construction project that’s just getting underway.

The heads of Chicago’s largest exchanges are calling for a review of the process that has allowed prediction market platforms to grow quickly by listing financial contracts without explicit regulatory ...

PsiQuantum has signed a research agreement with National Cancer Center Japan to develop drug discovery algorithms, underscoring demand for the emerging technology.

With two deals already under its belt, Ariel Investment’s Project Level is looking at the WNBA for its next investment, as the fund’s manager says the high-flying but undervalued league represents one ...

President Donald Trump’s push for lower U.S. drug prices has unexpectedly helped Astellas Pharma Inc. secure higher reimbursement pricing for its new eye medicine in Japan.

Chicago apartment investor Waterton paid $85 million for the 197-unit Flair Tower at 222 W. Erie St. in River North, the same price seller GID paid in 2011.

A measure proposed by Mayor Brandon Johnson meant to increase protections for poll workers and voters was put on pause this week after members of the City Council expressed reservations over how it ...

Medline is building a new distribution center in Texas, the company said today. It is the Northfield-based medical supplier’s first expansion project as a public company.