Therefore, the aim of this study was to perform an extensive multi-omic analyses on cryopreserved pre-mortem human left ventricular myocardium to uncover the influence of DM in end-stage HF and to ...

imageimageIn spermatogenesis, loss of promoter DNA methylation reactivates retrotransposons in patterns shaped by chromatin modifications and the binding of DNA methylation-sensitive transcription ...

Silencing evolutionary young retrotransposons by cytosine DNA methylation is essential for spermatogenesis, as failure to methylate their promoters leads to reactivation, meiotic failure, and ...

Lymphedema is a chronic lymphatic disorder characterized by persistent tissue swelling, pain, and recurrent infections, often secondary to cancer treatment, surgery, or obesity. Obesity-associated ...

Lysophosphatidylinositol (LPI) bioactive lipids are implicated in energy homeostasis and metabolic disorders, but their roles in insulin signaling remain unclear. This study reveals hepatic ...

The traditional treatment for systolic heart failure compromise heart contractility resulting in reduced cardiac output and exacerbate the symptoms. The newly developed drug-like compound (BR43) ...

imageimageIgA proteases are produced by some gut bacteria and interfere with the ability of the immune system to target bacteria. This study characterizes the recognition mechanisms of two M64 ...

In the central nervous system, the classical cell type distinction is between neurons and glia. Within a cell type group, subtype definitions have been largely conceptualized by the criteria used for ...