Mission is a city on the Rosebud Indian Reservation in northern Todd County, South Dakota, United States. The population was 1,156 at the 2020 census. Mission is home of the Sinte Gleska University. It is the largest incorporated community in the county, but is sma…Mission is a city on the Rosebud Indian Reservation in northern Todd County, South Dakota, United States. The population was 1,156 at the 2020 census. Mission is home of the Sinte Gleska University. It is the largest incorporated community in the county, but is smaller than the unincorporated community of Rosebud, the capital of the Rosebud Sioux Tribe.
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