Memphis is a city in the U.S. state of Tennessee. It is the county seat of Shelby County, in the southwesternmost part of the state, and is situated along the Mississippi River. With a population of 633,104 at the 2020 U.S. census, Memphis is th…Memphis is a city in the U.S. state of Tennessee. It is the county seat of Shelby County, in the southwesternmost part of the state, and is situated along the Mississippi River. With a population of 633,104 at the 2020 U.S. census, Memphis is the second-most populous city in Tennessee after Nashville.