Learn more about eLife assessments The distribution of synaptic and extra-synaptic AMPA receptors (AMPARs) on neuronal plasma membranes is correlated with learning and memory. Although AMPAR ...

Recording the spiking activity of muscle fibers at high resolution in awake, behaving mice, reveals that locomotor speed is driven by highly variable subsets of motor units.

Department of Molecular, Cellular, and Developmental Biology, The University of Toledo, United States; Department of Neurosciences and Psychiatry, The University of Toledo, United States; ...

The steroid hormone dafachronic acid may carry the effects of reduced mTOR activity between tissues to coordinate metabolism and longevity across the body.

Bovine mammary tissue can support infection and replication of diverse influenza A viruses and may provide an environment in which different viral strains can co-infect cells.

This valuable study substantially improves the phylogenetic framework for Kinetoplastea through greatly expanded sampling of free-living neobodonids; the phylogenomic analyses provide convincing ...

Sanchez-Vasquez et al establish an innovative approach to induce aneuploidy in preimplantation embryos. This important study extends the author's previous publications evaluating the consequences of ...

This important study uses the brain endocast of a ~1.9-million-year-old hominin fossil from Kenya, attributed to genus Homo, to show that the organization of the Broca's area in members of early Homo ...

Microfossils from the Paleoarchean Eon are the oldest known evidence of life. Despite their significance in understanding the history of life on Earth, any interpretation of the nature of these ...

Crystal structures of γ-protocadherin cell-cell recognition dimers reveal the determinants of clustered protocadherin homophilic specificity and cis interaction region structures alongside mutagenesis ...

Structures known as chromocenters, comprising satellite DNA and proteins such as D1 or HMGA1, help to contain DNA inside the nucleus between cell divisions.

Max Planck Institute of Biochemistry, Germany; Max Planck Institute for Biophysical Chemistry, Germany; ...