REM (rapid eye movement) and non-REM (NREM) sleep stages contribute to systems memory consolidation in hippocampal-cortical circuits. However, the physiological mechanisms underlying REM memory ...

Genetic and biochemical analyses show that loss of the E3 ubiquitin ligases ZNRF3 and RNF43 enhances EGFR signaling by impairing EGFR ubiquitination and degradation, revealing a new cancer-promoting ...

EM, biochemical, and cell-based assays to examine how Gβγ interacts with and potentiates PLCβ3. The authors present evidence for multiple Gβγ interaction surfaces and argue that Gβγ primarily enhances ...

The biosynthesis of an important biopolymer called hyaluronan requires an enzyme that discriminates between two different substrates.

Patterns of neural activity called theta oscillations have a role in memory encoding but – contrary to current thinking – do not appear to have a role in memory retrieval.

Findings provide a first step in understanding the motivations behind cooperation in adolescents and adults, paving the way for future research to explore these behaviours in real-world situations.

Norio Takeshita explores the microbiology of Japan’s national fungus and how it reflects centuries of human cultivation.

This mutation prevented VPS34 complex I binding to Rab1 but, surprisingly, it strengthened the interaction between VPS34 complex II and Rab5. The researchers carried out a series of experiments to ...

Mechanosensitive recruitment of DLC1 to focal adhesions creates a positive feedback loop that locally amplifies Rho activation in response to tension.

A system to enrich yeast in metaphase of mitosis, meiosis I, or meiosis II reveals reduced spindle assembly checkpoint robustness in meiosis I and distinct kinetochore composition and phosphorylation ...

The ability to predict brain activity from words before they occur can be explained by information shared between neighbouring words, without requiring next-word prediction by the brain.

Different impacts of the same molecular and circuit mechanisms on sleep–wakefulness control in early-life juveniles and adults.