In summary, our proteogenomic analysis of clinical tumor samples provides insights into air-pollution-associated lung cancers, especially those induced by coal smoke and offers an opportunity to ...

Working memory representations are not hard copies of sensory information, even in early visual cortex, but can be recoded into more abstract and goal-directed formats aligned to behavioral goals.

Depletion of the TGFβ signal-transducer, SMAD4, in granulosa cells of growing follicles reduces the number of filopodia, termed transzonal projections, that stably attach to and mediate communication ...

These results demonstrate not only that the mechanical fingerprint can be used to dissect the effect of cytoskeletal drugs on different properties but also the combined information obtained is a first ...

The yeast SWR1C chromatin remodeling enzyme catalyzes the ATP-dependent exchange of nucleosomal histone H2A for the histone variant H2A.Z, a key variant involved in a multitude of nuclear functions.

Chromosomal instability induced in solid tumors can combine with macrophages that are made highly phagocytic to thereby initiate elimination of and immunity against poorly immunogenic tumors in ...

A new protocol can customize the flavor of lab-grown meat by controlling the level of fat deposited between muscle cells.

Organ function declines with age, and large-scale transcriptomic analyses have highlighted differential aging trajectories across tissues. The mechanisms underlying shared and organ-selective ...

Neurexins are essential for shaping the functional properties of glycinergic synapse in the auditory brainstem, further attesting their universal role as critical presynaptic organizers in all major ...

This valuable simulation study proposes a new coarse-grained model to explain the effects of CpG methylation on nucleosome wrapping energy and nucleosome positioning. The evidence to support the ...

Department of Pediatrics, the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China Type 1 diabetes mellitus (T1DM), known as insulin ...

Detailed binding experiments reveal new insights into the Norrin/Wnt signaling pathway that helps to control vascularization in the retina.