Learn more about eLife assessments Mosquito-borne virus transmission is increasing globally. Due to a lack of effective vaccines or targeted treatments, mitigation relies on reducing human exposure to ...

The oceans buffer against climate change via biogeochemical cycles underpinned by microbial metabolic activities. While planetary-scale surveys provide baseline microbiome data, inferring metabolic ...

The manuscript presents a compelling application of the microfluidic mother machine as a "selection" machine. While individual elements of the work have existed for many years across various research ...

Plasma cell-free RNA (cfRNA) is a promising source of non-invasive biomarkers, but its clinical translation is hindered by technical challenges and a lack of protocol standardization, which ...

Automated Behavioural Response (ABR) systems, which combine camera traps with automated sound playbacks, offer a solution but have been primarily used on large terrestrial mammals. Here, we ...

An in vivo small-molecule drug screen in developing zebrafish larvae identifies dozens of unique chemical modulators capable of reducing atherogenic apolipoprotein B levels.

Although prenatal alcohol exposure (PAE) has been proposed as an early-life risk factor for Alzheimer’s disease and related dementias (AD/ADRD), the mechanistic underpinnings are underexplored.

The findings documented here are interesting and valuable with respect to revealing genetic players that may underlie AD. However, there are concerns related to the analysis pipeline and the basic ...

This important study identifies and characterizes a set of amino acid states that can rescue protein function in the presence of substantially deleterious mutations. Some of these super-compensatory ...

Overall, these in vitro experiments demonstrate that pharmacological activation of TRPML1 stimulates AMPK via a Ca 2+ -CaMKKβ-dependent pathway, thereby promoting GLUT4 translocation to the PM. This ...

Once more I find myself in my office with a slightly embarrassed and politely amused research student giving the same feedback as last year: ‘You’re not writing a murder mystery.’ Each year, thousands ...

CRISPR/Cas9-induced DNA double-strand breaks (DSBs) are widely used for genome engineering, yet their capacity to provoke sister chromatid exchange (SCE) and associated genome instability remains ...