Overall, these in vitro experiments demonstrate that pharmacological activation of TRPML1 stimulates AMPK via a Ca 2+ -CaMKKβ-dependent pathway, thereby promoting GLUT4 translocation to the PM. This ...

Humans make thousands of decisions under ambiguity every day, where most times the probabilities of getting beneficial outcomes are not fully known. Although ambiguity aversion is well characterized ...

CRISPR/Cas9-induced DNA double-strand breaks (DSBs) are widely used for genome engineering, yet their capacity to provoke sister chromatid exchange (SCE) and associated genome instability remains ...

Once more I find myself in my office with a slightly embarrassed and politely amused research student giving the same feedback as last year: ‘You’re not writing a murder mystery.’ Each year, thousands ...

Bordetella pertussis hijacks the host innate immune protein PGLYRP1 via tracheal cytotoxin to suppress inflammation and evade killing, revealing a novel immune evasion strategy.

This important study on multisensory learning examines the effect of integrating color vision and olfaction in the center for learning and memory (the mushroom body) in the fruit fly brain, and finds ...

This important study demonstrates that nutrient resorption efficiency in the widespread wetland grass Phragmites australis is largely canalized by phylogeographic lineage, ecotype and geographic ...

Successful navigation of the social environment depends on the ability to rapidly evaluate conspecifics and adjust behaviour accordingly. Encounters with unfamiliar individuals are particularly ...

This important study provides new insight into how frontostriatal circuits encode elapsed time and exhibit decision-related dynamics during an auditory change-detection task. Analyses of ...

This is a valuable study addressing a debated question in brain repair research by testing whether NeuroD1 can convert brain immune cells into nerve cells using a virus-free genetic approach and live ...

EEG neurofeedback as a method to modulate brain activity prior to painful stimulation and examined its effect on pain perception in a well-powered, double-blind study. Results showed that real, but ...

This valuable study provides key insights into the role of the G protein-coupled receptor GPR34 in an Alzheimer's disease (AD) model. Notably, its findings differ, at least in part, from those of ...