The study provides important insight into the development of CD8 T cell virtual memory cells by identifying a dose-sensitive role for Bcl11b. The authors define the developmental stages affected by ...

This study presents valuable findings implicating Xkr and its newly identified binding partners in regulating the exposure of apoptotic signal for phagocytosis, suggesting that Xkr might facilitate ...

This valuable study combines free-flight kinematics, aerodynamic modeling, optogenetics, and connectomics to ask how Drosophila stabilize roll perturbations duri ...

This manuscript examines how overexpression of sphingosine 1-phosphate receptor 1 in a mouse model affects neutrophil distribution, metabolism and function. Given the significance of S1PR1 in ...

Researchers have created a detailed map of childhood Crohn’s disease before and after treatment which suggests anti-TNF therapy might push the pediatric cell ecosystem towards more resistant disease.

Learn more about eLife assessments Mosquito-borne virus transmission is increasing globally. Due to a lack of effective vaccines or targeted treatments, mitigation relies on reducing human exposure to ...

An in vivo small-molecule drug screen in developing zebrafish larvae identifies dozens of unique chemical modulators capable of reducing atherogenic apolipoprotein B levels.

Plasma cell-free RNA (cfRNA) is a promising source of non-invasive biomarkers, but its clinical translation is hindered by technical challenges and a lack of protocol standardization, which ...

This important study identifies and characterizes a set of amino acid states that can rescue protein function in the presence of substantially deleterious mutations. Some of these super-compensatory ...

Although prenatal alcohol exposure (PAE) has been proposed as an early-life risk factor for Alzheimer’s disease and related dementias (AD/ADRD), the mechanistic underpinnings are underexplored.

The oceans buffer against climate change via biogeochemical cycles underpinned by microbial metabolic activities. While planetary-scale surveys provide baseline microbiome data, inferring metabolic ...

The findings documented here are interesting and valuable with respect to revealing genetic players that may underlie AD. However, there are concerns related to the analysis pipeline and the basic ...