Rare gastrointestinal lesions are seldom seen in endoscopy, limiting data for AI and clinician training. Here, authors present EndoRare, a one-shot retraining-free framework that synthesizes diverse ...

CAR-modified NK cells offer several advantages over CAR T cells including better safety and off-the-shelf potential. In addition, CAR NK cells are expanding the reach of CAR technologies beyond the ...

PDAC frequently exhibits KRAS mutations, and although direct KRAS inhibitors (KRASi) are showing clinical promise, responses are often not durable and acquired resistance is common. Here, Qiang et al.

However, the persistence of senescent cells is associated with chronic inflammation, fibrosis, and immune dysfunction. Although agents targeting senescent cells have shown promise in preclinical ...

The bacterial SOS response, activated by DNA damage by antibiotic treatment or attack by the host immune system, promotes both bacterial survival and the emergence of resistance through mutagenic DNA ...

Cardiac fibrosis is a common feature across many forms of cardiovascular disease (CVD), increasing tissue stiffness, disrupting myocardial architecture, and contributing to systolic and diastolic ...

(LC)-informed strategy for ionizable lipid discovery. An adenine base editor (ABE) fused to NanoLuc was constructed as a representative large mRNA reporter, and a combinatorial library of more than ...

The guard bees represent only about 1-2% of the 10,000 total workers in a nest, a ratio decided by the bees that tend brood ...

PROLONG, a data-driven probabilistic model of technology growth, projects wind and solar expansion consistent with 2 °C pathways and faster than current policy scenarios. The 1.5 °C pathway lies ...

A cancer patient in France has become the first person known to contract the Shamonda virus, following an outbreak in ...